Cellular Responses to Stress
1. Discuss how a cell will change or alter itself in response to stress. Address different types of adaptation or change along with what might be the reason that brings about the changes.
2. Select two types of cellular injury and describe potential treatments for the injury that are currently in use or under investigation.
3. Nursing has long realized the importance of linking research to practice. Recent research has shown that northern hemisphere populations have a significant deficiency in vitamin D in their diet; obesity is linked with fatty liver development; children’s sports such as soccer are associated with high incidence of concussion; and air pollution contributes to high rates of asthma. Critically analyze how this type of research is associated with the pathologic concept of cellular injury.
Inflammation / Cell Proliferation / Tissue Repair and Regeneration
1. Create a table depicting the difference in capacity to regenerate for labile, stable, and permanent cell types.
2. A 79-year-old woman has type I diabetes and an above-the-knee amputation of her right leg. She has had a right-sided cerebral vascular accident and has paralysis of her left side. The client has developed a stage III decubitus ulcer of her coccyx region. Critically review the concepts of tissue repair and wound healing as they relate to client’s situation.
1. A woman has breast cancer. The doctor had cells from her tumor tested and discovered that they have very high levels of estrogen receptors.
2. How would each of the following therapies work on this cancer?
(a) Tamoxifen (an antiestrogen drug)
(b) An antibody to the tumor cells with a toxin attached to it
(c) Lumpectomy followed by local radiation
3. A second woman has breast cancer, but her tumor cells have normal levels of estrogen receptors. Instead, they have G proteins that are constantly active, producing high levels of the second messenger cyclic AMP. How could this cause the cells to grow?
4. Which of the three treatments in Question 3 probably would not work well for this client? Why?
5. A third woman with breast cancer has both of these cell types in her tumor and also is deficient in p53 protein. What is the significance of the decreased p53 levels? Do they help explain why she has both other cell types in her tumor?
6. If everything else about them is equal, which of these women is most likely to have more primary cancers somewhere else in her body? Why?
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